The 3-star Casa San Domenico 2 By Vallettastay hotel provides proximity to the Valletta Waterfront, which is located only 1.6 km away. Featuring Wi-Fi throughout the property, this Valletta guest house also has amenities such as a luggage room.

The centre of Valletta can be reached within a 5-minute walk, and natural attractions like the Argotti Botanic Gardens & Resource Centre are approximately a 5-minute drive away. Standing just 400 metres from the colonnaded Siege Bell War Memorial, the Casa San Domenico 2 By Vallettastay Valletta is just 0.9 km from the Roman Catholic St. John's Co-Cathedral. The hotel is situated a short way from the Barrakka Lift, and Valletta A1 bus station lies merely a 10-minute walk away. For those travelling from afar, Malta International airport is 15 minutes' drive away.

The rooms comprise a kitchen complete with ironing equipment and climate control, as well as a flat-screen TV with satellite channels. In addition, there are a stovetop and kitchenware for self-catering purposes. Providing a separate toilet and a shower, the bathrooms also have a hair dryer and towels.

Casa San Domenico 2 By Vallettastay hotel is 450 m from The Little RED DOOR, which serves delectable meals.