The 3-star Casa San Domenico Double Room E Valletta hotel provides proximity to the Valletta Waterfront, which is located only 1.6 km away. Featuring Wi-Fi throughout the property, this Valletta guest house also has amenities such as a luggage room.

The centre of Valletta can be reached within a 5-minute walk, and natural attractions like the Manoel Island are nearly a 10-minute drive away. Standing merely 400 metres from the colonnaded Siege Bell War Memorial, the Casa San Domenico Double Room Valletta is just 0.9 km from the Roman Catholic St. John's Co-Cathedral. The hotel is situated a short way from the Barrakka Lift, and Valletta A1 bus station lies a mere 10 minutes' walk away. For those travelling from afar, Malta International airport is 15 minutes' drive away.

The rooms at Casa San Domenico Double Room E hotel include air conditioning, as well as media facilities like a flat-screen TV with satellite channels. Ironing facilities and an air conditioner are featured for guests' comfort. Providing a separate toilet and a shower, the bathrooms are also appointed with a hair dryer and towels.

Offering European meals, The Little RED DOOR is situated 450 m from the accommodation.