Located only 1 km from the colonnaded Siege Bell War Memorial, the 4-star smoke-free Palazzo Rosaria Boutique Hotel Valletta is a mere 6 minutes' walk from the Maltese National Museum of Archaeology. Business travellers will appreciate conveniences such as Wi-Fi in public areas and access to a computer workstation and a photocopy machine.

The comfortable hotel has a convenient location within a few blocks of Argotti Botanic Gardens & Resource Centre, while shopping venues like the urban shopping mall "Plaza Commercial Centre" are about a 10-minute walk away. Sights, merely 450 metres from the Palazzo Valletta, include the Renzo Piano–designed City Gate. Guests might as well enjoy proximity to Herbert Ganado Gardens, situated nearly 5 minutes away by car. In close proximity to the hotel there is the 16th-century high baroque St. John's Co-Cathedral. Valletta Terminal bus station is merely 350 metres from the Palazzo.

The air-conditioned rooms are fitted with air conditioning; such modern facilities as a flat-screen TV with satellite channels, and include private bathrooms with a bidet, a walk-in shower, and a separate toilet. The bedrooms come with sofa beds.

The property also offers a buffet breakfast. The dessert restaurant Caffe Cordina is a few moments from Palazzo Rosaria Boutique Hotel.